Essential Medications for Long Flights: What to Bring

“Spectacular achievement is always preceded by unspectacular preparation.”

Robert H. Schuller

It is all about preparation: learn which meds you need for everyday health issues that arise during flights and long travel days.

Are you a minimalist packer? I offer you congrats because I am not. This article is especially for you, but it will serve everyone. As a nurse, I will pack for all the what-ifs. That has served me well when I have been injured (embarrassingly too often) or ill while abroad. It has also benefited people who travel with me and strangers along the way. Most of us have been on those flights when we hear that scary overhead announcement: Is there a doctor, nurse, or EMT on the plane? I have answered that call several times and am glad I could help. I also sat next to people who were miserable during their day of travel, and they had nothing with them to alleviate their symptoms.

Luckily, I could offer those people something to help ease their discomfort. In the case of family and friends who travel with me, they know not to worry about it, which reduces what they have to pack. This is especially the case for Ryan, co-founder of Wanderers Compass. It was during an overseas trip in which I left weeks before him that I realized I needed to make him a “flight kit” since he usually doesn’t carry meds as I do. I contemplated how to prepare a travel med packet for him that’s small yet complete. It was easier than I thought, and I realized I should share this with our readers, too. Here is a simple yet effective travel tip for essential medications on long flights, so you are prepared for common scenarios.

*Though all the meds we discuss are over-the-counter, it does not mean they are safe for YOU. ALWAYS check with your medical care provider (not Dr. Google) to make sure you have no contraindications to any of these meds. *

Let’s go over the most common issues that arise during flights or long days of travel.

• Headache or body aches
• Motion/air sickness
• Acid Indigestion
• Nausea
• Sore neck or back from sitting for extended periods.
• Diarrhea
• Coughing or sore throat
• Cold symptoms/Sinus issues

All the above can make for a long and miserable day of travel that may start your trip on a sour note. Being able to manage these things can make all the difference. An over-the-counter med can reduce or eliminate most of these issues, and you can arrive at your destination ready to hit the ground running.

Is there a way to avoid all these issues? Travel preparation should begin in the weeks before you travel. Check out our article on travel health here.

What medications for a long flight should be readily handy?

The list below is the essential medications I always have on hand for long flights, whether traveling for a 2-hour flight or a 24-hour travel day.

Ibuprofen, Aspirin, or Naproxen (also known as Aleve)

Not all, just one of them. I prefer Ibuprofen (also known as Advil) myself. These are all NSAIDS and can not be taken together. If you are on a prescription NSAID, you can not take these if your physician contraindicates it.

Tylenol/Acetaminophen

This is a pain and fever-reducing medication. It can be used along with an NSAID unless you have a contraindication. For that sore back or back headache, it comes in handy.

Tums

I get one of the small rolls as it fits nicely into the Ziploc bag and doesn’t turn into powder. This is good for an acid stomach or indigestion.

Alka Seltzer

That airplane meal is not sitting well? This is the best thing for an unhappy tummy. Remember, it has aspirin, so you can not take other NSAIDs simultaneously.

Dramamine or Meclizine

These are for motion sickness. The picture shows a small container of Dramamine, but I prefer Meclizine as it is non-drowsy. But if you want to sleep too, Dramamine will help with that.

Benadryl

This has many uses, and I am never without some nearby. First, if someone has an allergic reaction, this will be the first line of defense, especially at 37,000 feet. It can also be used for a runny nose or as a sleep aid. For some people, it works well for nausea, but it will make you drowsy. If you are nauseous and want to sleep, it is a good choice.

Pepto Bismol

This helps with nausea and indigestion. It can reduce diarrhea. It doesn’t cause drowsiness.

Loperamide

This medicine is used to treat diarrhea. As we know, it can strike at any time. If during air travel, it is challenging. Loperamide usually stops it quickly.

Cough/Throat drops

I have been on flights when I started developing a cough or sore throat. Often, it is the dry air. These will help, along with some water.

Sudafed

This is a nasal decongestant. At times, on the day of travel, you have exhausted yourself so much that you now have a stuffy nose. The biggest concern here is your ears. If I have any congestion, I take it 1/2 hour before take-off and 1/2 hour before descent. Anyone with congested ears knows how severe the pain can be on an airplane, so it is best to be prepared.

Moisturizing eye drops

Dry eyes can be so rough on a plane and also impact sleep. I like the small single-use containers in the picture.

Lib Balm

This isn’t a medication, but I get badly chapped lips on long flights. Using lip balm helps prevent lips from cracking, reducing the risk of issues like bleeding or infection.

Sounds like a lot of medications for a long flight. What matters is that you are prepared and that it all fits into a 4×3 zip bag, as shown in the image. You can use a sandwich bag, but I find them too big, thin, and not compact. The bag I use efficiently fits in your hand or a pocket. You are fully prepared for the most common health scenarios while traveling.

Things to consider when packing essential medications for long flights – Safety First

If you are traveling with kids, please make sure they don’t have access to any medications. With all meds, that is the case.

Note prescription meds should not be transported this way. They must be labeled with the prescription when traveling, especially internationally.

If you are uncomfortable not having some of the meds labeled, you can buy individually wrapped Tylenol, Benadryl, Aleve, and Ibuprofen on Amazon or in most pharmacies. Most medications in the image were labeled.

Always follow the package instructions unless your medical provider has told you otherwise.

People often ask what medications they can take on the plane. The answer is pretty much anything. Over-the-counter meds have no restrictions unless they are liquids over 3 ounces or the meds can’t cross state borders. You can bring any prescription medication as long as you have the prescription to document that it is yours. Internationally, it can vary if you are going to any place where any of these drugs are banned, so that may well be worth researching.

What are these little zip bags seen in the images?

This is one of my favorite finds in recent years. I buy them on Amazon and have used them for years. My favorite use is for my daily vitamins on a trip. I grab a minibag on the way to breakfast; no time is wasted sorting them out daily. They are great if you take collagen powder or Metamucil daily. Saves space and time. They are thick, and the ziplock works very well. I also find many other uses, such as premeasured spices I need when cooking at someone else’s home. These bags are great for kids’ snacks, holding small office supplies, jewelry, and charging cables, safety pins, to name a few uses.

They can be found on Amazon at this link. A box of 200 is around $7.00. They have become indispensable to my travel. They will be perfect for your essential medications for long flights.

Closing Thoughts

If you embark on a dream trip, this travel tip on which essential medications to take on long flights will serve you well. It will help ensure your journey starts on the right foot. It takes up little space and prepares you for any likely scenarios. Traveling feeds the soul while seeing the wonders this beautiful world offers. Being comfortable and healthy will make it even more remarkable—happy and healthy travels.

© 2025 Wanderers Compass All Rights Reserved

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